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Document Type

Research

Abstract

In recent years attention has been directed to the role of the thyroid gland in the metabolism of carotene and vitamin A. Drill and Truant (1947) reported that carotene administration failed to prevent xerophthalmia in thyroidectomized rats, whereas vitamin A supplementation cured the eye lesions. Moreover, Johnson and Baumann (1947), using liver storage of vitamin A as the criterion of conversion of carotene to vitamin A, found that hyperthyroid rats accumulated larger stores of vitamin A than normal rats receiving equivalent doses of carotene, but rats rendered hypothyroid by feeding either thiourea or thiouracil stored little vitamin A. Similar experiments by Kelley and Day (1948) also indicated that thiouracil interfered with the conversion of carotene to vitamin A in rats. Conversely, Wiese and associates (1948), using growth as a measure of carotene utilization, found that the ability of rats to convert carotene to vitamin A was not impaired by feeding thiouracil.

Publication Date

1951

Journal Title

Proceedings of the Iowa Academy of Science

Volume

58

Issue

1

First Page

235

Last Page

243

Copyright

© Copyright 1951 by the Iowa Academy of Science, Inc.

Language

EN

File Format

application/pdf

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