Due to the tremendous amount of research work being done on cancer in recent years, a number of diagnostic tests have been developed by different groups of individuals. One of the most promising of the cancer detection methods utilizes the principle of (1) selective differentiation of blood sera by means of transmitted filtered ultra violet light. Cancer sera transmit more light and more fluorescence than normal or non-malignant sera, and the fluorescence in cancer sera appears blue or violet; in non-malignant sera the fluorescence is yellow or olive green. In 1800 sera, of which 1600 were non-malignant, the percentage of false negatives was about 14 per cent and the percentage of false positives was 4%. Another test (2) is an easy one in which drops of blood from a finger puncture are allowed to dry on a glass slide and viewed. Non-malignant blood produces a dark mass centrally located in the dried drop, whereas cancerous blood produces no centrally located mass. Under the microscope non-malignant blood produces rouleau formation with no variation in the size or shape of the red blood corpuscles. Malignant blood produces no rouleau formation; the red blood cells are arranged in a disorderly fashion, abnormal in size, shape, and arrangement. This test gave 96.5% correct results. (3) A third test is the plasma methylene blue reducing time technique.
Proceedings of the Iowa Academy of Science
©1950 Iowa Academy of Science, Inc.
Peterson, Hjalmer V. and Morgan, Harold W.
"The Huggins Test for Cancer and Related Protein Determination,"
Proceedings of the Iowa Academy of Science, 57(1), 215-223.
Available at: https://scholarworks.uni.edu/pias/vol57/iss1/24