Accompanying certain types of inflammation the heat-regulating mechanism of the body is disrupted so that heat accumulates and the body temperature rises. The individual is said to have a fever. Since the early work of Ledingham (1908) in which he showed that the rate of phagocytosis increased with a rise in temperature, a moderate fever has come to be regarded as a defense mechanism of the body. It is, therefore, of some significance that the normal and deviations from normal temperature be known for laboratory animals which are to be used to measure the response of an individual host to an artificial infection. Since mouse typhoid, a highly fatal disease occurring among mice and caused by the micro-organism Salmonella typhimurium has been likened in some respects to the typhoid of humans caused by Eberthella typhosum, it is all the more important that the temperature aspect of mouse typhoid be investigated. The present paper presents some preliminary results from experiments in which rectal temperatures were obtained for normal and inoculated mice of resistant and susceptible inbred strains.
Proceedings of the Iowa Academy of Science
©1947 Iowa Academy of Science, Inc.
Weir, J. A.
"The Temperature of the Mouse in Health and Disease,"
Proceedings of the Iowa Academy of Science, 54(1), 383-388.
Available at: https://scholarworks.uni.edu/pias/vol54/iss1/59