Normally, the process of mitosis is an orderly, integrated series of events, that is, karyokinesis and cytokinesis are usually linked together and function as one continuous process. Occasionally, however, either one or both of these processes may be interfered with in some way so that a dissociation takes place between the two. This gives rise to an abnormal situation so that each process may proceed independently of the other or one may be inhibited while the other goes on uninterrupted. The most common abnormal condition of this type is the inhibition of cell cleavage while nuclear division continues, resulting in the production of polyploids. This occurs rarely as a natural phenomenon, but more frequently as the result of disease, or quite commonly under experimental conditions. A few of the experimental agents used for inducing modification or inhibition of cell division are injury, heat, cold, ultraviolet and X-radiations, narcotics, anesthetics, hypertonic and hypotonic solutions, colchicine, and high centrifugal forces.
Proceedings of the Iowa Academy of Science
©1941 Iowa Academy of Science, Inc.
Hilbe, James J.
"The Effects of Ultracentrifuging Germinating Seeds of Onion and Rye,"
Proceedings of the Iowa Academy of Science, 48(1), 457-466.
Available at: https://scholarworks.uni.edu/pias/vol48/iss1/119