New organo-lead compounds have been prepared by means of the Grignard reagent. These compounds are being tested in cancer studies, as anti-knock agents, and as reagents to combat some plant diseases. Grignard reagents are being prepared from tetra-p-bromophenyl-lead, diphenyl-di-p-bromophenyl-lead, and halogeno- alkyl lead types by reaction with the special magnesium-copper alloy using mercuric salts as catalysts. Solubilizing groups like dialkylamino, diethyl-aminoethyl, and various carboxylic acid groups are being attached to the R groups which in turn are attached to lead. For allied purposes the same types are being prepared where the lead has been replaced by tin, antimony, selenium and tellurium.
Proceedings of the Iowa Academy of Science
© Copyright 1927 by the Iowa Academy of Science, Inc.
Gilman, Henry and Robinson, Jack
"Organo-Lead Compounds in the Treatment of Cancer,"
Proceedings of the Iowa Academy of Science, 34(1), 221-221.
Available at: https://scholarworks.uni.edu/pias/vol34/iss1/50