Faculty Publications

Title

Cellular uptake and toxicity study of cis-bis(6-aminoquinoline) dichloroplatinum(II)

Document Type

Article

Journal/Book/Conference Title

Journal of Inorganic Biochemistry

Volume

42

Issue

4

First Page

231

Last Page

235

Abstract

A fluorescent analog of cis-diamminedichloroplatinum(II), cis-bis(6-aminoquinoline)dichloroplatinum(II), was prepared from K2[PtCl4] and 6-aminoquinoline (AQL). HPLC of the thiourea derivative of the new complex showed that it has the cis-configuration. The Pt-AQL complex and the parent ligand AQL were evaluated for biological activity and cellular uptake, using the ciliate Tetrahymena pigmentosa. The complex was relatively nontoxic at the tested levels below 5 × 10-4 M, but did exhibit inhibition of culture growth at 5 × 10-4 M. Measurement of cellular uptake of the Pt-AQL complex demonstrated incorporation into the cell, with localization primarily within the vacuoles of the cells. Comparable measurement of the parent ligand AQL showed little measurable cellular uptake. © 1991.

Original Publication Date

1-1-1991

DOI of published version

10.1016/0162-0134(91)84037-A

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