Faculty Publications

Title

Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota

Document Type

Article

Keywords

Fabaceae, Glepidotin, Glycyrrhiza lepidota, HIV-1, Prenylated

Journal/Book/Conference Title

Phytochemistry

Volume

58

Issue

1

First Page

153

Last Page

157

Abstract

The organic soluble extract from the leaves of Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete 1H NMR and 13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay. © 2001 Elsevier Science Ltd.

Original Publication Date

8-10-2001

DOI of published version

10.1016/S0031-9422(01)00177-7

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