Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota
Fabaceae, Glepidotin, Glycyrrhiza lepidota, HIV-1, Prenylated
The organic soluble extract from the leaves of Glycyrrhiza lepidota showed moderate activity in the US National Cancer Institute in vitro anti-HIV-1 bioassay. Chromatographic separation of this extract resulted in the identification of a new diprenylated bibenzyl as the compound responsible for the observed anti-viral activity. Extensive spectroscopic experiments provide the complete 1H NMR and 13C NMR spectral assignments to support the proposed structure. Known compounds glepidotin B and glepidotin A were also isolated from the extract and shown to be inactive in the anti-viral assay. © 2001 Elsevier Science Ltd.
Original Publication Date
DOI of published version
Manfredi, Kirk P.; Vallurupalli, Vasanti; Demidova, Maria; Kindscher, Kelly; and Pannell, Lewis K., "Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota" (2001). Faculty Publications. 3508.