Open Access Presidential Scholars Thesis
Robert J. Simpson
Estrogen--Physiological effect; Osteoporosis--Treatment;
If nuclear binding sites for estrogens exist in bone cells, then the origin of estrogen-deficiency-induced osteopenia may be at the level of bone matrix protein synthesis. Since collagen is the most abundant protein in the bone matrix, and since hydroxyproline is an imino acid nearly exclusive to collagen, a monitoring of the metabolism of hydroxyproline in ovariectomized and estrogen treated rats may provide insight into the patterns of estrogen-deficiency-induced osteopenia. The purpose of our study was to test the hypothesis that ovariectomy will increase urinary hydroxyproline excretion in the rat and that this increase will be reversed by estrogen treatment therapy.
Date of Award
Department of Biology
Presidential Scholar Designation
A paper submitted in partial fulfillment of the requirements for the designation Presidential Scholar.
1 PDF file (17 pages)
©1991 Gregg Horras
Horras, Gregg, "Patterns of hydroxyproline excretion in ovariectomized and estrogen treated rats" (1991). Presidential Scholars Theses (1990 – 2006). 5.