Effects of Prostaglandins on Cyclic AMP Content of Superior Cervical Ganglia of the Cow and Cat

Authors

Asa C. Black Jr., University of IowaFollow

Document Type

Research

Keywords

Cyclic AMP, Prostaglandins, Superior Cervical Ganglion, Synaptic Transmission

Abstract

Dopamine and prostaglandin E₂ (PGE₂) produced time- and concentration-dependent increases in cyclic AMP levels of bovine superior cervical ganglia (SCG). Maximal increases in cyclic AMP levels were produced within 1 min by PGE₂, compared to l0 min for dopamine. Dopamine and PGE₂ were synergistic in their effects on cyclic AMP levels. By contrast, prostaglandin F_2a had no effect on cyclic AMP levels. In the feline SCG, the modest increases in cyclic AMP levels produced by dopamine were not statistically significant. Neither PGE₂ nor PGF_2a increased cyclic AMP levels in feline SCG. Interpretation: Dopamine increased cyclic AMP synthesis in bovine SCG by stimulating a dopamine receptor-adenylate cyclase complex. PGE₂ increased cyclic AMP synthesis in bovine SCG by stimulating an adenylate cyclase complex. This complex may or may not be the same one stimulated by dopamine. The stimulatory effect of PGE₂ is specific for prostaglandins of the E series, since PGF_2a had no effect. Neither dopamine nor PGE₂ stimulated cyclic AMP synthesis in the feline SCG because this ganglion lacks significant adenylate cyclase activity.

Publication Date

March 1982

Journal Title

Proceedings of the Iowa Academy of Science

Volume

89

Issue

1

First Page

20

Last Page

22

Copyright

©1982 Iowa Academy of Science, Inc.

Language

en

File Format

application/pdf

Recommended Citation

Black, Asa C. Jr. (1982) "Effects of Prostaglandins on Cyclic AMP Content of Superior Cervical Ganglia of the Cow and Cat," Proceedings of the Iowa Academy of Science, 89(1), 20-22.
Available at: https://scholarworks.uni.edu/pias/vol89/iss1/7