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Document Type

Research

Keywords

Cyclic AMP, Prostaglandins, Superior Cervical Ganglion, Synaptic Transmission

Abstract

Dopamine and prostaglandin E2 (PGE2) produced time- and concentration-dependent increases in cyclic AMP levels of bovine superior cervical ganglia (SCG). Maximal increases in cyclic AMP levels were produced within 1 min by PGE2, compared to l0 min for dopamine. Dopamine and PGE2 were synergistic in their effects on cyclic AMP levels. By contrast, prostaglandin F2a had no effect on cyclic AMP levels. In the feline SCG, the modest increases in cyclic AMP levels produced by dopamine were not statistically significant. Neither PGE2 nor PGF2a increased cyclic AMP levels in feline SCG. Interpretation: Dopamine increased cyclic AMP synthesis in bovine SCG by stimulating a dopamine receptor-adenylate cyclase complex. PGE2 increased cyclic AMP synthesis in bovine SCG by stimulating an adenylate cyclase complex. This complex may or may not be the same one stimulated by dopamine. The stimulatory effect of PGE2 is specific for prostaglandins of the E series, since PGF2a had no effect. Neither dopamine nor PGE2 stimulated cyclic AMP synthesis in the feline SCG because this ganglion lacks significant adenylate cyclase activity.

Publication Date

March 1982

Journal Title

Proceedings of the Iowa Academy of Science

Volume

89

Issue

1

First Page

20

Last Page

22

Copyright

© Copyright 1982 by the Iowa Academy of Science, Inc.

Language

EN

File Format

application/pdf

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